5,066 results found
    1. Microbiology and Infectious Disease

    In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

    Kelsey A Haugh et al.
    Retroviruses exploit the lectin, Siglec-1/CD169, expressed on sentinel macrophages to promote infection during multiple routes of transmission.
    1. Structural Biology and Molecular Biophysics

    Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

    Fenghui Zhao et al.
    The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

    Monique S Straub et al.
    The cryo-EM structures of XKR9 define the architecture and caspase-mediated activation of a protein family that is involved in the exposure of phosphatidylserine during apoptosis leading to the engulfment of apoptotic cells by macrophages.
    1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel et al.
    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.
    1. Neuroscience

    Distinct signatures of calcium activity in brain mural cells

    Chaim Glück et al.
    Increases of extracellular potassium silence capillary pericyte calcium signaling, suggesting a participation of capillary pericytes in the potassium-mediated neurovascular communication.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

    Peter J Diebold et al.
    One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.
    1. Neuroscience

    Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant

    Stijn Adriaan Nuiten et al.
    When all features of conflicting sensory input are task-irrelevant, the brain can still process its sensory information, whereas conflict detection requires that minimally one stimulus feature is task-relevant or associated with a response.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Computational and Systems Biology
    2. Neuroscience

    Mice in a labyrinth show rapid learning, sudden insight, and efficient exploration

    Matthew Rosenberg et al.
    Mice exploring a labyrinth freely for the first time learn a complex action sequence after a handful of rewards, exhibiting a learning rate 1000-fold higher than in commonly-used paradigms.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI et al.
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.

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