The HOXB13 binding partner MEIS1 suppresses prostate cancer proliferation, invasion, and metastasis by promoting expression of the anti-oncogenic extracellular proteoglycan Decorin.
In the Drosophila central brain, synaptic connectivity extracts visual-spatial information from the axons of looming sensitive LC6 neurons that terminate in a glomerulus with minimal retinotopy.
Yeast promoters can harbor multiple natural DNA variants that influence gene expression, interact genetically, evolve under negative selection, alter transcription factor motifs, and remain challenging to predict.
The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
The survival of Drosophila amacrine neurons is controlled by neurotrophic signaling mediated by interactions between the cell surface protein DIP-γ and its partner Dpr11, which is expressed on presynaptic photoreceptors.
Analyses combining genomic and epidemiological data of Mycobacterium bovis, which causes bovine tuberculosis, revealed evidence of transmission within and between cattle and badger populations.
An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
