858 results found
    1. Cell Biology
    2. Developmental Biology

    R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

    Ramin Dubey et al.
    Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.
    1. Neuroscience

    The sifting of visual information in the superior colliculus

    Kyu Hyun Lee et al.
    The superior colliculus reveals hallmarks of sophisticated visual computation, including selectivity, invariance, and stimulus-specific habituation to behaviorally relevant stimuli.
    1. Neuroscience

    Alterations in the amplitude and burst rate of beta oscillations impair reward-dependent motor learning in anxiety

    Sebastian Sporn et al.
    State anxiety alters the dynamics of beta oscillations during reward-dependent motor learning, thereby impairing proper updating of motor predictions when learning in unstable environments.
  1. people working from home

    neuromatch: Algorithms to match scientists

    We developed machine-learning algorithms to help connect scientists during online research conferences.
    1. Neuroscience

    Behavioral evidence for memory replay of video episodes in the macaque

    Shuzhen Zuo et al.
    Macaque monkeys temporally compress past experiences and use a forward-replay mechanism during judgment of temporal-order between episodes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: SARS-CoV-2 (COVID-19) by the numbers

    Yinon M Bar-On et al.
    Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
    1. Neuroscience

    Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo

    Jin Bao et al.
    During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.
    1. Developmental Biology
    2. Neuroscience

    Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies

    Jodie A Schiffer et al.
    C. elegans nematodes use a sensory-neuronal circuit to determine whether to defend themselves from hydrogen peroxide attack or to freeload off orthologous protective defenses from bacteria in their surrounding environment.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

    Frank L van de Veerdonk et al.
    The kinin-kallikrein system is a crucial target for the treatment of COVID-19.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

    Joseph L Harman et al.
    In the ancestor of mammals, a multifunctional innate immune protein evolved when a mutation enhanced the protein’s pro-inflammatory activity and proteolytic regulation without disrupting the protein’s antimicrobial activity.

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