115 results found
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

    Ziyu Wen, Pingchao Li ... Caijun Sun
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M Jore
    A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

    Angel D'Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

    Carley N Gray, Manickam Ashokkumar ... Michael Emerman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection

    Kavidha Reddy, Guinevere Q Lee ... Thumbi Ndung’u
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    MeiQing Han, Xia Wang ... Fan Yang
    Gut microbiota dysbiosis increased Nos2 expression through the 'gut–lung axis', and altered intracellular antimicrobial and anti-inflammatory environment by abnormal NO, ROS, and Defb1, thereby promoting Mycobacteria colonization in mouse lungs.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Incomplete
    1. Immunology and Inflammation

    Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
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