84 results found
    1. Chromosomes and Gene Expression

    CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

    Françoise S Howe et al.
    CRISPR interference (CRISPRi), which uses small guide RNAs to target catalytically dead Cas9 protein to chromatin, disrupts existing transcription units and generates new sites for initiation and termination of transcription on both strands of DNA.
    1. Developmental Biology
    2. Genetics and Genomics

    Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos

    Theodora Koromila et al.
    The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Transcription mediated insulation and interference direct gene cluster expression switches

    Tania Nguyen et al.
    The formation of mutually exclusive coding and non-coding transcription units contributes to transcriptional interference and insulation at gene clusters and manages state-switching in response to environmental change.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Cell Biology
    2. Developmental Biology

    Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

    Federico Tessadori et al.
    The three-dimensional and asymmetrical transformations undergone by the zebrafish linear heart tube during looping morphogenesis are under the control of cardiac-intrinsic cues.
    1. Cancer Biology
    2. Developmental Biology

    A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

    Katarina Valoskova et al.
    T antigen glycosylation, which marks metastatic cancer cells, is modulated on a small set of proteins by a conserved multipass transmembrane protein to allow tissue invasion by Drosophila macrophages.
    1. Cell Biology

    GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

    Alondra Schweizer Burguete et al.
    Expanded repeat RNAs associated with human neurodegenerative diseases can become incorporated into transported granules in neurons, perturbing their function to cause neuritic branching defects.
    1. Cell Biology
    2. Neuroscience

    Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

    Amanjot Singh et al.
    Ataxin-2 interacts with neuronal mRNA in RNP granules.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat et al.
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee et al.
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.

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