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The CtIP DNA repair enzyme is required for the removal of transcription-associated lesions in eukaryotic cells.

Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.

The eukaryotic translation initiation factor eIF4E induces hyaluronic acid (HA) synthesis to drive cancer metastasis which can be reversed following eIF4E inhibition and HA degradation.

IFNγ increases the responsiveness of human B cells to IL-2, TLR7/8 and IL-21 signals and therefore enhances antibody production in inflammatory settings associated with autoimmune or chronic disease.

The archaeal MCM helicase can load in multiple orientations on DNA but translocation proceeds with a leading N-terminal domain, which affects double hexamer activation at origins of replication.

Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.

Atoh1+ HC precursors survive post severe injury and activate the Yap-Lin28 pathway to restore progenitor for initiating regeneration.

Functional characterization of the alpha/B1.1.7 SARS-CoV-2 variant revealed an eightfold affinity increase of the N501Y RBD to human ACE-2 and that even a low inoculation dose of the alpha variant induces severe disease and fast progression in transgenic hACE2 mice.

Embryo-derived TNF promotes CPLA_2α phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.

Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.