337 results found
    1. Neuroscience

    Structure and function of axo-axonic inhibition

    Casey M Schneider-Mizell, Agnes L Bodor ... Nuno Maçarico da Costa
    Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.
    1. Neuroscience

    Common cell type nomenclature for the mammalian brain

    Jeremy A Miller, Nathan W Gouwens ... Amy Bernard
    A new nomenclature convention for mammalian cell types utilizing shared taxonomies and quantitative cell features is applied to high-quality, open data from the mouse and human brain.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

    Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
    Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio, Marie-Ka Tilak ... Frédéric Delsuc
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Neuroscience

    A split-GAL4 driver line resource for Drosophila neuron types

    Geoffrey W Meissner, Allison Vannan ... FlyLight Project Team
    Thousands of cell-type-specific split-GAL4 driver lines and a massive, searchable image collection enable Drosophila neuroscientists to target neurons of interest with increased precision.
    1. Genetics and Genomics
    2. Neuroscience

    Fruitless mutant male mosquitoes gain attraction to human odor

    Nipun S Basrur, Maria Elena De Obaldia ... Leslie B Vosshall
    Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
    1. Biochemistry and Chemical Biology

    Global analysis of cytosine and adenine DNA modifications across the tree of life

    Sreejith Jayasree Varma, Enrica Calvani ... Markus Ralser
    By using mass spectrometry, we determined the global levels of various DNA modifications across species and tissues.
    1. Neuroscience

    The functional organization of descending sensory-motor pathways in Drosophila

    Shigehiro Namiki, Michael H Dickinson ... Gwyneth M Card
    Systematic analysis of descending neuron anatomy reveals the basic functional map of descending sensory-motor pathways in flies and provides genetic tools for targeted interrogation of neural circuits.
    1. Neuroscience

    Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

    Michael Bucher, Stephan Niebling ... Marina Mikhaylova
    Autism-associated SHANK3 missense mutations result in differential protein folding, stability, and intramolecular dynamics affecting its turnover at the synapse.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

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