Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
Iris E Glykofridis, Jaco C Knol ... Rob MF Wolthuis
Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
Matthew V Kotlajich, Daniel R Hron ... Robert Landick
Bridged H-NS filaments inhibit transcript elongation by bacterial RNA polymerase by enhancing backtracking and increasing Rho-dependent termination at a subset of pause sites that are normally poor Rho substrates.
Coarse-grained modeling of mammalian kinetochore-fiber shapes generated under microneedle manipulation reveals the need for lateral anchorage 1-3 μm from the kinetochore to robustly preserve their orientation in the spindle center, promoting mechanical integrity in the dynamic spindle.
Tylor R Lewis, Sebastien Phan ... Vadim Y Arshavsky
Maturation of light-sensitive 'disc' membranes in vertebrate photoreceptors requires a precise balance between their content of the visual pigment rhodopsin forming the disc body and tetraspanin proteins forming the disc rim.
Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
