284 results found
    1. Neuroscience

    A limbic circuit selectively links active escape to food suppression

    Estefania P Azevedo et al.
    Lateral septum neurotensin neurons are active in response to stress where escape is a viable strategy and decrease consumption via effects on hypothalamic pathways regulating food intake.
    1. Immunology and Inflammation

    Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

    Gabriela Krejčová et al.
    Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Profilin and formin constitute a pacemaker system for robust actin filament growth

    Johanna Funk et al.
    Profilin release from the filament end controls the speed of actin growth at physiological conditions.
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens et al.
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Immunology and Inflammation

    The kinase PDK1 is critical for promoting T follicular helper cell differentiation

    Zhen Sun et al.
    PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

    Spencer Hill et al.
    Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.
    1. Cell Biology
    2. Developmental Biology

    YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

    Kishor K Sivaraj et al.
    The interplay between the transcriptional co-regulators YAP1/TAZ and the hypoxia-controlled transcription factor HIF1α differentially regulates endothelial cell behavior in the hypoxic environment of bone compared to other organs.
    1. Computational and Systems Biology
    2. Medicine

    Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Dimitrios Chantzichristos et al.
    A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
    1. Neuroscience

    Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice

    Rahul Munshi et al.
    Magnetothermal neuromodulation providing quick, tetherless, precise on and off switching of neurons deep in the brain of freely moving animals is orthogonal to optogenetics and a breakthrough in remote modulation techniques.
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.

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