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    1. Cell Biology

    The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

    Rolf M Schmidt et al.
    Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.
    1. Neuroscience

    Neurocalcin regulates nighttime sleep and arousal in Drosophila

    Ko-Fan Chen et al.
    The neuronal calcium sensor Neurocalcin regulates sleep and arousal thresholds during the night in Drosophila.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

    Valeria Kalienkova et al.
    cryo-EM reveals the properties of distinct conformations occupied during activation of the lipid scramblase nhTMEM16 and provides new insights into its interactions with the lipid environment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Functional proteomic atlas of HIV infection in primary human CD4+ T cells

    Adi Naamati et al.
    Identification and characterisation of proteins and processes regulated by HIV in primary human CD4+ T cells using an HIV reporter virus for one-step, antibody-free magnetic selection.
    1. Cancer Biology

    Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

    Xuefei Yan et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
    1. Computational and Systems Biology

    Spatiotemporal establishment of dense bacterial colonies growing on hard agar

    Mya R Warren et al.
    A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane bridging by Munc13-1 is crucial for neurotransmitter release

    Bradley Quade et al.
    Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

    David Alejandro Bejarano et al.
    Interaction of HIV capsids with the cellular protein cleavage-and-polyadenylation factor 6 at the inner side of nuclear pores promotes nuclear entry of the viral replication complex in primary human macrophages.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Genetic and environmental perturbations lead to regulatory decoherence

    Amanda Lea et al.
    Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.