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    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt et al.
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi et al.
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

    Victor Ovchinnikov et al.
    Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
    1. Cell Biology

    The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

    Maria Benito-Jardón et al.
    The fibronectin synergy site is only required in vivo when forces exceed or αvβ3 integrin levels fall below certain thresholds.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Cell Biology
    2. Computational and Systems Biology

    Principles of cellular resource allocation revealed by condition-dependent proteome profiling

    Eyal Metzl-Raz et al.
    Steadily growing cells prepare for conditions that demand increased translation by producing excess ribosomes, at the expense of lower steady-state growth rate.
    1. Microbiology and Infectious Disease

    An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence

    Jeanyoung Jo et al.
    During growth in biofilms and host infection, the opportunistic pathogen Pseudomonas aeruginosa employs respiratory heterocomplexes that support extracellular electron shuttling and pathogenicity.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Cell Biology
    2. Developmental Biology

    Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

    Yuwei Jiang et al.
    The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.
    1. Cell Biology

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    Herschel S Dhekne et al.
    Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.