Browse the search results

Page 2 of 465
    1. Structural Biology and Molecular Biophysics

    Discovery and characterization of Hv1-type proton channels in reef-building corals

    Gisela Rangel-Yescas, Cecilia Cervantes ... Leon D Islas
    Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.
    1. Neuroscience

    Acetylcholine acts on songbird premotor circuitry to invigorate vocal output

    Paul I Jaffe, Michael S Brainard
    The neuromodulator acetylcholine contributes to state-dependent modulation of motor vigor and variability by direct action on songbird premotor cortex, bypassing basal ganglia circuitry.
    1. Neuroscience

    Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior

    Vamsi K Daliparthi, Ryosuke O Tachibana ... Todd F Roberts
    Precisely sequenced patterns of neuronal activity associated with the production of a skilled behavior begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.
    1. Neuroscience

    Motor Performance: Acetylcholine in action

    Erin M Wall, Sarah C Woolley
    The neurotransmitter acetylcholine influences how male finches perform courtship songs by acting on a region of the premotor cortex called HVC.
    Version of Record
    Insight
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang, Houda G Khaled ... Richard HR Hahnloser
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pneumococcal genetic variability in age-dependent bacterial carriage

    Philip HC Kremer, Bart Ferwerda ... John A Lees
    Future vaccination strategies in pneumococcal disease should target specific bacterial serotypes for different host age groups.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    An entropic safety catch controls hepatitis C virus entry and antibody resistance

    Lenka Stejskal, Mphatso D Kalemera ... Joe Grove
    The entry glycoproteins of hepatitis C virus, E1E2, possess a novel regulatory mechanism in which protein disorder is harnessed to control their activity and their ability to evade antibodies.
    1. Genetics and Genomics

    Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

    Mingqi Zhou, Ian Tamburini ... Marcus M Seldin
    A population resource to investigate mechanisms of organ communication.
    1. Cell Biology

    A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle

    Kent W Jorgenson, Jamie E Hibbert ... Troy A Hornberger
    A novel imaging method for measuring myofibril size/number reveals that the radial growth of muscle fibers that occurs in response to increased mechanical loading is largely mediated by myofibrillogenesis.
    1. Medicine
    2. Microbiology and Infectious Disease

    Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

    Barnaby Flower, Le Manh Hung ... Graham S Cooke
    Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.