Hantaan virus nucleocapsid cryo-EM structure determined at 3.3 Å resolution reveals how nucleoproteins assemble into a metastable helix containing a continuous RNA-binding groove compatible with genome encapsidation and compaction.

The flow of neural activity across the cortico-cerebellar loop enables mice to reach for objects with skill and precision.

Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.

An open-source tool based on computational vision and machine learning shows high accuracy and sensitivity in the analysis of ultrasonic vocalizations.

Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.

Ca_V1.3 channels of the short isoform are coupled via their C-terminal domains in a Ca²⁺-CaM-dependent manner, which facilitates Ca²⁺ influx and increases the discharge of hippocampal neurons.

The Ca²⁺-driven functional coupling of CaV1.2 channels is a mechanism of channel memory that may modulate the amplification of Ca²⁺ influx.

Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.

Optogenetic inhibition demonstrates that the cortex is necessary and sufficient for the initiation and execution of a learned, skilled action.

Cross-sectional transcriptome analysis of mice, covering the whole lifespan, reveals that inter-tissue divergence during development is accompanied by a weaker but widespread convergence during ageing.