306 results found
    1. Cell Biology
    2. Developmental Biology

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Cancer Biology

    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

    SungEun Kim et al.
    Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
    1. Developmental Biology

    Hedgehog signaling regulates gene expression in planarian glia

    Irving E Wang et al.
    Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.
    1. Developmental Biology
    2. Evolutionary Biology

    Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

    Cheng-Yi Chen et al.
    The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
    1. Developmental Biology
    2. Genetics and Genomics

    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

    Rachel K Lex et al.
    GLI3 represses Hedgehog target gene expression by regulating histone modifications at a subset of tissue-specific GLI-bound enhancers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Coordinated hedgehog signaling induces new hair follicles in adult skin

    Xiaoyan Sun et al.
    Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals

    Lin Fu et al.
    Methylation of Gli3 by Set7 enhances the activation of Hedgehog signaling and contributes to tumor growth and metastasis in vitro and in vivo.
    1. Developmental Biology

    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

    Saishu Yoshida et al.
    DYRK2 regulator governs the mammalian ciliogenesis to maintain proper embryogenesis via activation of the Hh signaling during development in vivo.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall et al.
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.

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