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ARL13B regulates Sonic hedgehog signaling from outside primary cilia
Eduardo D Gigante et al.
ARL13B regulates cell ciliation and cilia length from within cilia and Sonic hedgehog response from outside of cilia indicating the two processes can be spatially uncoupled.
Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in
Seol Hee Im et al.
equivalent of Substance P signaling modulates nociceptive sensitization by regulating Hedgehog signaling within nociceptive sensory neurons.
Biochemistry and Chemical Biology
Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals
Lin Fu et al.
Methylation of Gli3 by Set7 enhances the activation of Hedgehog signaling and contributes to tumor growth and metastasis in vitro and in vivo.
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice
Yu Shi, Fanxin Long
Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin
Qi Deng et al.
Cartilage and bone tumors arise from chondrocyte or osteoblast progenitors but not differentiated cells or multipotent mesenchymal stem cells (MSCs) via the IHH-Wnt/β-Catenin pathway.
Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2
Keisuke Onishi, Yimin Zou
Sonic Hedgehog signaling may temporally and spatially activate planar cell polarity signaling for cellular and tissue morphogenesis.
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
Maia Kinnebrew et al.
The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models
Kyeong-Hye Moon et al.
Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx
Jacqueline M Tabler et al.
Genetic studies in mice reveal the molecular and embryological mechanisms of vocal fold development and function, thereby informing our understanding of vocal communication and congenital voice defects.
Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
Steven A Hill et al.
Astrocytes modulate synaptic remodeling of developing circuits in a cell type-specific manner, with long lasting deficits in synaptic plasticity.
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