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    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of limb development in cephalopod mollusks

    Oscar A Tarazona et al.
    Cuttlefish embryos reveal that cephalopod mollusks evolved specialized arms and tentacles by activating the same genetic circuits that control development of limbs in arthropods and vertebrates.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

    Nir Drayman et al.
    Single-cell analyses of cells infected by Herpes Simplex Virus 1 revealed extreme heterogeneity among infected cells, including the robust activation of developmental gene programs in highly infected cells.
    1. Developmental Biology
    2. Neuroscience

    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

    Meenakshi Prajapati-DiNubila et al.
    Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.
    1. Cancer Biology
    2. Cell Biology

    Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer

    Christina R Adams et al.
    The GLI2 transcription factor is a master regulator of the aggressive basal-like subtype of pancreatic cancer and enables adaptation to oncogenic KRAS ablation.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander et al.
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

    Mohsen Afshar Bakooshli et al.
    Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
    1. Computational and Systems Biology
    2. Developmental Biology

    Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

    Erika Tsingos et al.
    3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
    1. Stem Cells and Regenerative Medicine

    Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

    Stephanie T Kuwahara et al.
    Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Developmental Biology
    2. Neuroscience

    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

    Hirofumi Noguchi et al.
    Sufu controls dentate gyrus stem cell quiescence by acting as a positive regulator of Shh signaling and loss of Sufu leads to dramatic failure to produce sufficient quiescent stem cells.