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    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus et al.
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Cell Biology
    2. Developmental Biology

    PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix

    S Nahuel Villegas et al.
    A signalling cascade involving PI3K/Akt1 remodels the extra-cellular matrix to achieve atypical cellular responses and control cell fate specification within the embryonic endoderm.
  1. Media coverage: December roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in December 2017, including the Financial Times, Science and The Hindu.
  2. Suzanne Eaton: In memory of a remarkable colleague

    As a tribute to Suzanne Eaton’s many contributions to science and to scientists, we asked several of her colleagues to reflect on her work and life.
  3. Media coverage: January roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in January 2018, including Science, Smithsonian magazine and The Conversation.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.