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    1. Chromosomes and Gene Expression

    High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    Douglas Maya Miles et al.
    Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.
    1. Neuroscience

    Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa

    Paul A Nakamura et al.
    Regulating rod gene expression with a small molecule ligand for the orphan nuclear receptor Nr2e3 rescues photoreceptors from degeneration in a mouse model of retinitis pigmentosa.
    1. Cell Biology
    2. Developmental Biology

    Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

    Preetish Kadur Lakshminarasimha Murthy et al.
    Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.
    1. Cell Biology
    2. Neuroscience

    A genetic toolkit for tagging intronic MiMIC containing genes

    Sonal Nagarkar-Jaiswal et al.
    Building on previous work (Nagarkar-Jaiswal et al., 2015), we report an elegant genetic strategy for endogenous tagging of MiMIC containing genes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Developmental Biology
    2. Neuroscience

    Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons

    N Sumru Bayin et al.
    Injury at birth induces immature neurons to divide and regenerate cerebellar Purkinje cells in a time-dependent manner.
    1. Human Biology and Medicine
    2. Neuroscience

    Regenerating hair cells in vestibular sensory epithelia from humans

    Ruth Rebecca Taylor et al.
    Immunolabelling and morphological assessment, complemented by complete transcriptomic analysis, demonstrates that supporting cells can be induced to convert towards a hair cell-like phenotype in human vestibular sensory epithelia.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart et al.
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis

    Shelby A Blythe, Eric F Wieschaus
    The patterns of chromatin architecture that underlie the initial embryonic cell fate decisions are established during a period of intense cell cycle activity, and these patterns are stably maintained even in highly condensed mitotic chromatin.