217 results found
    1. Stem Cells and Regenerative Medicine

    Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

    Stephanie T Kuwahara et al.
    Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.
    1. Developmental Biology

    Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling

    Yi Wang et al.
    Cells in tendon sheaths, considered to be extrinsic tissues of tendon, possess stem or progenitor cell properties that are involved in tendon repair by activating the Hh-TGFb/Smad3 axis.
    1. Developmental Biology

    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

    Saishu Yoshida et al.
    DYRK2 regulator governs the mammalian ciliogenesis to maintain proper embryogenesis via activation of the Hh signaling during development in vivo.
    1. Developmental Biology

    Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

    Craig T Jacobs, Peng Huang
    Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal et al.
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
    1. Developmental Biology

    Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

    Ko W Currie et al.
    Planarian brain neurons modulate their turnover by signaling to nearby stem cells.
    1. Developmental Biology

    Patched1 and Patched2 inhibit Smoothened non-cell autonomously

    Brock Roberts et al.
    Ptch1/2 can lower the sensitivity of Smo to activation by Shh via the secretion of a sterol precursor.
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.
    1. Developmental Biology

    Cytoneme-mediated cell-cell contacts for Hedgehog reception

    Laura González-Méndez et al.
    Direct interaction between Hedgehog-sending and Hedgehog-receiving cytonemes is a fundamental mechanism for morphogen transfer and gradient establishment.
    1. Developmental Biology

    Hedgehog signaling regulates gene expression in planarian glia

    Irving E Wang et al.
    Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.

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