Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.
Clytia jellyfish regenerate body shape and organs through a mechanically driven process that coordinates tissue remodeling, localized proliferation, and precursor migration and promotes Wnt signaling at a muscle-based landmark.
Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.