2,268 results found
    1. Structural Biology and Molecular Biophysics

    Structure of the human lipid-gated cation channel TRPC3

    Chen Fan et al.
    Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai et al.
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Pharmacology: A Swiss army knife for targeting receptors

    Johansen B Amin, Lonnie P Wollmuth
    A compound can change the activity of NMDA receptors in some regions of a synapse without affecting those in other regions.
    Insight
    Available as:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression

    BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

    Jackson A Hoffman et al.
    Within distinct chromatin landscapes, the BRG1 chromatin remodeling enzyme patterns hormone-dependent chromatin interactions, pioneer factor recruitment, and transcriptional activity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Influenza virus: Interfering with transmission

    Andreas Wack
    The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice.
    Insight
    Available as:
    • HTML
    • PDF
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

    Riley Perszyk et al.
    A series of novel compounds selective for N-methyl-D-aspartate-type glutamate receptor includes positive and negative allosteric modulators that act at the same site, show use-dependence, increase agonist potency, and have differential activity based on the agonist concentration.
    1. Structural Biology and Molecular Biophysics

    Multivalency regulates activity in an intrinsically disordered transcription factor

    Sarah Clark et al.
    Binding of multiple LC8 copies to the intrinsically disordered region of the transcription factor ASCIZ exemplifies a new and potentially widespread molecular mechanism for negative feedback regulation.
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii.

    Sarah L Sokol et al.
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Ecology

    First bone-cracking dog coprolites provide new insight into bone consumption in Borophagus and their unique ecological niche

    Xiaoming Wang et al.
    Fossilized feces (coprolites) of extinct bone-crushing dogs, Borophagus parvus, from late Miocene (6 million years ago) of California demonstrates consumption and preservation of bones in digestive tracts and potential social hunting behavior by these predators.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Pollution: Transgenic pigs to the rescue

    Björn Petersen
    Genetically engineered pigs that digest their food better could help to reduce phosphorus and nitrogen pollution.
    Insight
    Available as:
    • HTML
    • PDF

Refine your results by:

Type
Research categories