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    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

    Andisheh Abedini et al.
    Toxic IAPP intermediates have some molecular features that are similar to, and others that are distinct from, toxic species reported for other amyloidogenic polypeptides.
    1. Biophysics and Structural Biology
    2. Plant Biology

    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

    Julia Santiago et al.
    A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
    1. Neuroscience

    Human observers have optimal introspective access to perceptual processes even for visually masked stimuli

    Megan A K Peters, Hakwan Lau
    Despite the widely held belief among researchers in consciousness that healthy observers can show unconscious perception, a study using a novel method to control for response biases finds no evidence for this phenomenon.
  1. Peer Review: The pleasure of publishing

    Vivek Malhotra, Eve Marder
    When assessing manuscripts eLife editors look for a combination of rigour and insight, along with results and ideas that make other researchers think differently about their subject.
    Editorial
    Available as:
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    1. Neuroscience

    Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

    Norihiro Takakuwa et al.
    The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
    1. Developmental Biology and Stem Cells

    Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

    Stephanie F Bellmaine et al.
    Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.
    1. Biophysics and Structural Biology

    Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

    Gregory M Martin et al.
    Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (KATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Kinesin-12 Kif15 is a processive track-switching tetramer

    Hauke Drechsler et al.
    The first in vitro analysis of full-length human Kif15 provides insight into how hKif15 and its inhibitory binding partner hTpx2 modulate mitotic spindle architecture.
    1. Immunology and Inflammation

    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

    Shiho Chiba et al.
    An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.
    1. Neuroscience

    Neuromodulatory connectivity defines the structure of a behavioral neural network

    Feici Diao et al.
    Using targeted functional manipulations of neural activity to map neuromodulatory connections can deliver considerable insight into the functional architecture of a behaviorally important network even in the absence of information about its synaptic connectivity.