98 results found
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak et al.
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Developmental Biology

    YAP controls retinal stem cell DNA replication timing and genomic stability

    Pauline Cabochette et al.
    The Hippo pathway downstream effector YAP regulates S-phase progression to protect neural stem cells of the retina from experiencing genomic instability.
    1. Developmental Biology

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman et al.
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė et al.
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

    Justin A Bosch et al.
    The F-box protein Fbxl7 is a direct effector of the protocadherin Fat and functions in downstream pathways that regulate tissue shape and size.
    1. Computational and Systems Biology

    Systematic morphological profiling of human gene and allele function via Cell Painting

    Mohammad Hossein Rohban et al.
    Gene function can be revealed based on characteristic phenotypes using a Cell Painting microscopy assay.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

    Thomas K Ni, Charlotte Kuperwasser
    The study of a recurrent breast cancer MAGI3 truncation reveals the role of MAGI3 in regulating the Hippo effector YAP and highlights premature mRNA cleavage and polyadenylation as a mechanism underlying cancer development.
    1. Cell Biology

    Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

    Susumu Hirabayashi, Ross L Cagan
    The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
    1. Cancer Biology
    2. Cell Biology

    Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

    Marie-Julie Nokin et al.
    Carbonyl stress mediated by Methylglyoxal affects Hsp90 activity, inhibits the Hippo pathway and promotes tumor growth and metastasis in breast cancer.
    1. Cell Biology

    Two-signal requirement for growth-promoting function of Yap in hepatocytes

    Tian Su et al.
    The Yap pathway requires two signals to promote organ growth: a cell intrinsic Hippo signal and a signal induced by injury or inflammation.

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