127 results found
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt et al.
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    YAP drives cutaneous squamous cell carcinoma formation and progression

    Zoé Vincent-Mistiaen et al.
    High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Discovery of several thousand highly diverse circular DNA viruses

    Michael J Tisza et al.
    A bioinformatics pipeline has annotated over 2,500 complete genomes of circular DNA viruses belonging to dozens of established and emerging viral families.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila

    Robin E Harris et al.
    The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.
    1. Neuroscience

    BAD and KATP channels regulate neuron excitability and epileptiform activity

    Juan Ramón Martínez-François et al.
    Altered activity of ATP-sensitive K+ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.
    1. Developmental Biology

    Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing

    Rosalind Hale et al.
    Opposing gradients of Fat and Dachsous phosphorylation are sufficient to explain the observed pattern of Fat-Dachsous planar polarisation across the Drosophila wing.
    1. Microbiology and Infectious Disease

    Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii

    Nicolò Tosetti et al.
    A combination of high-resolution microscopy and reverse genetics identified key components of the alveolin network playing an essential role in the assembly of subpellicular microtubules and conoid in Toxoplasma gondii..
    1. Developmental Biology

    A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms

    Hadi Boukhatmi, Sarah Bray
    Adult muscle progenitors evade differentiation by expressing a short RNA isoform of Zfh1 which is insensitive to regulation by a micro-RNA.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang et al.
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.
    1. Cell Biology

    53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

    Chii Shyang Fong et al.
    Tumor Protein p53 Binding Protein 1 and Ubiquitin Specific Peptidase 28 engage p53 to promote mitotic efficiency.

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