Elucidating the molecular mechanism by which the Hippo signaling effector Yorkie (Yki) functions as a transcriptional coactivator in growth control reveals the importance of a histone-modifying enzyme for this process.
A contractile structural protein of the membrane-associated cytoskeleton is a Hippo signaling component that works through the regulation of non-muscle myosin activity in Drosophila.
The Hippo pathway downstream effector YAP regulates S-phase progression to protect neural stem cells of the retina from experiencing genomic instability.
The cell junction-associated protein Amotl2a controls tissue size in the zebrafish lateral line primordium by limiting the activity of the Hippo effector Yap1 and the Wnt effector Lef1.
The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
The functional relevance of stem cell niche perturbation in sarcomagenesis is defined and the mouse model presented provides a rationale for the use of combination therapy for the treatment of genetically heterogeneous sarcomas.
The study of a recurrent breast cancer MAGI3 truncation reveals the role of MAGI3 in regulating the Hippo effector YAP and highlights premature mRNA cleavage and polyadenylation as a mechanism underlying cancer development.
