2,171 results found
    1. Neuroscience

    An emerging view of neural geometry in motor cortex supports high-performance decoding

    Sean M Perkins, Elom A Amematsro ... Mark M Churchland
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

    Yul HR Kang, Anne Löffler ... Michael N Shadlen
    When making two decisions about one object, two streams of information can be acquired in parallel but must be incorporated into the two decisions serially, consistent with a central bottleneck.
    1. Neuroscience

    The connectome of the adult Drosophila mushroom body provides insights into function

    Feng Li, Jack W Lindsey ... Gerald M Rubin
    Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
    1. Neuroscience

    Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans

    Daniel Martins, Anthony S Gabay ... Yannis Paloyelis
    Single measurements of baseline salivary and plasmatic oxytocin are not sufficiently reliable to provide valid trait markers of the physiology of the oxytocin system in humans.
    1. Neuroscience

    Single neurons and networks in the claustrum integrate input from widespread cortical sources

    Andrew M Shelton, David K Oliver ... Adam M Packer
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

    Josep Rizo, Levent Sari ... Milo M Lin
    Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Developmental Biology
    2. Neuroscience

    Expansion microscopy of C. elegans

    Chih-Chieh (Jay) Yu, Nicholas C Barry ... Edward S Boyden
    Fixed, intact animals of C. elegans can be physically expanded with high isotropy, to enable super-resolved imaging of general proteins and nucleic acids throughout the organism, on conventional microscopes.
    1. Cell Biology
    2. Neuroscience

    Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

    Alexander M Walter, Rainer Müller ... Jakob Balslev Sørensen
    Increasing PI(4,5)P2 on a sub-second timescale using a novel, membrane-permeant UV activatable PI(4,5)P2 molecule augments exocytosis which requires the PI(4,5)P2 interacting exocytotic proteins Munc13-2 and synaptotagmin-1.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Species and cell-type properties of classically defined human and rodent neurons and glia

    Xiao Xu, Elitsa I Stoyanova ... Nathaniel Heintz
    Gene expression and epigenetic profiling of defined cell types in the central nervous system of mouse, rat, and human reveals inter-species and inter-individual differences.

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