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Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.

The results reported here provide new and foundational insights into the neural architecture that underpins hippocampal dependent memory systems in the human brain by providing detailed maps that show how different cortical areas anatomically connect within the hippocampus.

Gene expression was analyzed in hippocampal principal cells, enabling cellular phenotyping and revealing novel organizational principles; complementing this, a publicly available website is released to provide outside analysis and visualization of hippocampal RNA-seq data in an accessible fashion.

Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.

Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.

Imaging of neurons within the hippocampus, a memory region of the brain, reveals how the brain updates memories during different learning conditions compared to when learning is blocked by amnestic drugs.

Hippocampal place cells modulate their firing rate during replay events to reflect the increases, or decreases, in firing rate experienced between contexts during behavior.

A single-nucleus transcriptomic atlas reveals the molecular signatures and trajectory dynamics of the neurogenic lineage in the human hippocampus during neonatal development, adulthood, aging, and after injury.

Triggered by (long-duration) hippocampal ripples, spindles facilitate communication between the hipppocampus and neocortex during natural sleep.