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    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal et al.
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai et al.
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Structural Biology and Molecular Biophysics

    Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

    Andrew John Knappenberger et al.
    RNA aptamers that are closely related and share a common scaffold can readily adapt to recognize new ligands through changes in just a few nucleotides.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

    Jamie A Macpherson et al.
    Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin et al.
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An elusive electron shuttle from a facultative anaerobe

    Emily Mevers et al.
    The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
    1. Genetics and Genomics

    Amino acid synthesis loss in parasitoid wasps and other hymenopterans

    Xinhai Ye et al.
    The synthesis capability of some amino acids is lost during the insect evolution, and hymenopteran parasitoids can make up for these deficiencies by altering free amino acid concentrations in host.
    1. Genetics and Genomics

    Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

    Christian Brion et al.
    A CRISPR-based dual reporter assay enables genetic mapping of DNA variants that specifically affect mRNA or protein levels in trans.
    1. Biochemistry and Chemical Biology

    Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

    Henry H Le et al.
    Caenorhabditis elegans homologs of carboxylesterases that localize to intestinal organelles orchestrate the assembly of modular signaling molecules from building blocks that integrate diverse metabolic pathways.
    1. Evolutionary Biology

    The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

    Alessandro W Rossoni et al.
    Horizontal gene transfer (HGT) analysis in polyextremophile red algae (Cyanidiales) provides explanations for the nonexistence of cumulative effects and eukaryotic pangenomes, and highlights differences between HGT and native genes.