34 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

    Shun-Hsiao Lee et al.
    The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.
    1. Chromosomes and Gene Expression

    Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

    Darpan Medhi et al.
    Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
    1. Epidemiology and Global Health

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Chromosomes and Gene Expression

    Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

    Peter Tonzi et al.
    Translesion polymerase kappa promotes replication fork restart to maintain genome stability during conditions of nucleotide deprivation.
    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    1. Cell Biology

    Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing

    Annina Denoth-Lippuner et al.
    The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.
    1. Chromosomes and Gene Expression

    High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

    Yi Yin et al.
    Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
    1. Evolutionary Biology

    New fossil remains of Homo naledi from the Lesedi Chamber, South Africa

    John Hawks et al.
    The discovery of new skeletal remains of Homo naledi in the Lesedi Chamber, South Africa, adds more evidence to our understanding of the morphology and behavior of this recently discovered species.
    1. Cell Biology

    Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

    Kenta Yamamoto et al.
    Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg et al.
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.

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