332 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji, Kristen L Howell ... Alice H Huang
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

    Rebecca Devlin, Catarina A Marques ... Richard McCulloch
    Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
    1. Evolutionary Biology

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

    Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole
    An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.
    1. Microbiology and Infectious Disease

    Robust manipulation of the behavior of Drosophila melanogaster by a fungal pathogen in the laboratory

    Carolyn Elya, Tin Ching Lok ... Michael Eisen
    A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes, Fei Zhou ... Ralph Bock
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Impact of the scale-up of piped water on urogenital schistosomiasis infection in rural South Africa

    Frank Tanser, Daniel K Azongo ... Christopher Appleton
    Scale-up of safe water supplies decreases a child's risk of urogenital schistosomiasis infection by eight-fold in a typical rural African population.
    1. Epidemiology and Global Health

    The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa

    Thomas S Churcher, Natalie Lissenden ... Hilary Ranson
    Mosquitoes with high levels of pyrethroid resistance reduce the ability of bednets to protect those using them and the wider community, which is predicted to substantially increase malaria cases.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots

    Philip Bejon, Thomas N Williams ... Steffen Borrmann
    Malaria 'hotspots' can be identified that range in size from a few homesteads to a village, and it will be necessary to eliminate hotspots at varying scales as we progress towards eliminating malaria.

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