TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
Rebecca Devlin, Catarina A Marques ... Richard McCulloch
Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole
An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.
A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.
A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
Thomas S Churcher, Natalie Lissenden ... Hilary Ranson
Mosquitoes with high levels of pyrethroid resistance reduce the ability of bednets to protect those using them and the wider community, which is predicted to substantially increase malaria cases.
Philip Bejon, Thomas N Williams ... Steffen Borrmann
Malaria 'hotspots' can be identified that range in size from a few homesteads to a village, and it will be necessary to eliminate hotspots at varying scales as we progress towards eliminating malaria.