Maneesh Kumar Singh, Victoria Ann Bonnell ... Celia RS Garcia
Multi-omic analyses reveal that the chromatin-associated microrchidia protein, MORC (PF3D7_1468100), at the blood stage of the human malaria parasite, Plasmodium falciparum, interacts with a range of nuclear proteins.
Temperature, the presence of an enemy species and the density of the mutualistic partner species interact to determine the expression of a protective mutualism.
Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
Bikash Shakya, Saurabh D Patel ... Elizabeth S Egan
The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.
Marc A Schureck, Joseph E Darling ... Sanjay A Desai
A high-resolution structure reveals how the RhopH complex traffics within Plasmodium-infected human erythrocytes to serve divergent, essential functions.
Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
Environmental gradients can modify a fundamental relationship between host community structure and disease, with implications for predicting disease risk in a changing world.
The synthesis capability of some amino acids is lost during the insect evolution, and hymenopteran parasitoids can make up for these deficiencies by altering free amino acid concentrations in host.
