10,270 results found
    1. Chromosomes and Gene Expression

    Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

    Daan Noordermeer et al.
    Hox genes are activated sequentially and, at the same time, undergo a transition from an inactive to an active chromatin compartment, most likely to prevent posterior genes being activated too early.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase

    Anna L Mallam et al.
    The core domains of an RNA helicase interact with a wide variety of NTPs and nucleic acids suggesting how related enzymes may have evolved to have diverse functions.
    1. Neuroscience

    Transformation of a temporal speech cue to a spatial neural code in human auditory cortex

    Neal P Fox et al.
    The human brain has a spatial code for representing temporal phonetic distinctions in speech.
    1. Structural Biology and Molecular Biophysics

    Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

    Ho Yee Joyce Fung et al.
    Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

    Xiaowei Hou et al.
    Structure of the Ca2+ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca2+ entry into immune and other non-excitable cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The guide sRNA sequence determines the activity level of box C/D RNPs

    Andrea Graziadei et al.
    Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
    1. Genetics and Genomics
    2. Plant Biology

    The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons

    Rita A Batista et al.
    Jumping of transposable elements provides DNA-binding sites for the MADS-box transcription factor PHERES1, allowing the regulation of imprinted genes and other key endosperm development genes.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

    Matthew J Shurtleff et al.
    A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.
    1. Developmental Biology

    The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

    Katrin Domsch et al.
    The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.
    1. Developmental Biology
    2. Evolutionary Biology

    Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

    Isabel Guerreiro et al.
    Despite their extreme morphologies, snakes display a global regulatory strategy of their Hox genes similar to that implemented by mammals with, however, important modifications in enhancer specificity.

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