Nup98-HoxA9 is recruited to Hox gene cluster regions together with the chromosomally pre-bound nuclear export factor Crm1, which induces aberrant expression of several Hox genes and affecting the differentiation of embryonic stem cells.
The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.
Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
Mapping individual neural stem cells to their corresponding embryonic and postembryonic progeny shows that these sets of neurons have profound molecular and anatomical similarities despite building different central nervous systems.
Tucked within a well-known story of diverging gene function is a single enhancer encoding two inseparable specificities that regulates two adjacent genes, each with different spatiotemporal expression patterns.