69 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation

    Skylar Xantus Kim et al.
    Two small, energy independent stress effectors are able to counteract all of the major insults imposed by severe water loss.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
    1. Cell Biology

    Glucose intake hampers PKA-regulated HSP90 chaperone activity

    Yu-Chen Chen et al.
    Food overconsumption impairs cellular protein folding through a novel aging-related signaling pathway.
    1. Biochemistry and Chemical Biology

    Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

    Akira Uchida et al.
    Hypervariable regions of mtDNA contribute to transcriptional regulation by serving as sites for TFAM binding and looping.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

    Krzysztof Brzezinka et al.
    Environmentally-mediated gene induction is extended beyond the duration of an external cue by sustaining a nucleosome-depleted chromatin structure.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

    Martin Borch Jensen et al.
    A signaling pathway involving PGAM5, ASK1 and JNK induces persistent FoxO activation, chaperone expression and lifespan extension following developmental mitochondrial stress, which can be blocked by mTOR signaling through GCN-2.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comprehensive fitness maps of Hsp90 show widespread environmental dependence

    Julia M Flynn et al.
    Environmental conditions strongly impact the fitness effects of Hsp90, resulting in the selection of Hsp90 sequences in nature that are robust to a variety of stressful conditions.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

    Joanna Krakowiak et al.
    Dynamic regulation of the heat shock response depends on a negative feedback loop in which Hsf1 activates expression of Hsp70 and Hsp70 specifically and directly represses Hsf1 transactivation.
    1. Chromosomes and Gene Expression

    Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo

    Natalia Petrenko et al.
    Mediator, a transcriptional coactivator complex, is essential for transcription but is not a required component of a functional preinitiation complex, indicating that Mediator is not equivalent to a general transcription factor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

    Blake W Tye et al.
    Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.

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