A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.

MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.

Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.

Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.

A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.

An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.

Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.

The Cajal body chaperone TCAB1 and scaffold protein Coilin are not required for telomerase activity in human cells.

The compactness of synaptic release sites coupled with their four-fold number in humans compared to rats provides unprecedented scaleability in operation of human synapses.

Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.