2,836 results found
    1. Neuroscience

    Cascade of neural processing orchestrates cognitive control in human frontal cortex

    Hanlin Tang et al
    A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.
    Research Article Updated
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

    Christine J Huh et al
    MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.
    Short Report Updated
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    1. Human Biology and Medicine
    2. Neuroscience

    Unique membrane properties and enhanced signal processing in human neocortical neurons

    Guy Eyal et al
    Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
    Short Report Updated
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    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.
    Tools and Resources Updated
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    1. Human Biology and Medicine

    Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

    Lauran Madden et al
    A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.
    Research Article Updated
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha et al
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
    Research Article
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz et al
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
    Research Article
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    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

    Jacob M Vogan et al
    The Cajal body chaperone TCAB1 and scaffold protein Coilin are not required for telomerase activity in human cells.
    Research Article Updated
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    1. Neuroscience

    Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles

    Gábor Molnár et al
    The compactness of synaptic release sites coupled with their four-fold number in humans compared to rats provides unprecedented scaleability in operation of human synapses.
    Short Report Updated
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    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    An integrative transcriptomic atlas of organogenesis in human embryos

    Dave T Gerrard et al
    Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.
    Tools and Resources
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