The structure of the trypanosome haptoglobin-haemoglobin receptor bound to its ligand reveals the molecular basis for ligand recognition in innate immunity and identifies molecular determinants that aid efficient uptake.
The cessation of major anthropogenic disturbances since European colonization in the forests of central Africa leads to a canopy closing, and to the disappearance of certain light-demanding tree species.
A catalytically dead paralog activates its cognate enzyme through an allosteric mechanism that combined structural and phylogenomic analysis indicates arose through acquisition of a dimerization domain, suggesting a general model for how complex allostery evolves.
The global ensemble forecasting niche modelling of 11 vector competent triatomine species revealed climatic suitable regions outside their native distribution including the cosmopolitan vector Triatoma rubrofasciata.
Cryo electron tomography provides the first high-resolution 3D axoneme structure from any pathogenic organism, revealing novel structures that support the unique motility of these pathogens through host tissues.