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    1. Neuroscience

    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

    Jeong-Kyu Han et al.
    Cerebellar STAT3 is indispensable for proper expression of fear memory network processing.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Developmental Biology

    Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

    Xiaobo Wang et al.
    Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell et al.
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
    1. Developmental Biology
    2. Genetics and Genomics

    Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

    Lauren M Saunders et al.
    Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Discovery of several thousand highly diverse circular DNA viruses

    Michael J Tisza et al.
    A bioinformatics pipeline has annotated over 2,500 complete genomes of circular DNA viruses belonging to dozens of established and emerging viral families.
    1. Cancer Biology

    Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

    Tushar D Bhagat et al.
    Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

    Rongbo Li et al.
    Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

    John D Chan et al.
    Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.