Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
The observation that an additional vaccine dose provides protection against Omicron variant reinfection in previously vaccinated and infected individuals will help guide future COVID-19 vaccination policies in China and globally.
Ana Fló, Lucas Benjamin ... Ghislaine Dehaene-Lambertz
Human neonates process regularities in speech's phonetic and voice content in parallel, but only phonetic regularities evoke a specific ERP component in a post-learning phase.
A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.
Predictive pharmacology based on behavioural fingerprinting can identify druggable pathways that are altered or renormalized in zebrafish larvae that harbor mutations in early and late-onset Alzheimer's disease risk genes.
Gabriella O Estevam, Edmond Linossi ... James S Fraser
A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
Vivian C Salgueiro-Toledo, Jorge Bertol ... Rafael Prados-Rosales
Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.
