517 results found
    1. Immunology and Inflammation

    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

    Ken-ichi Hirano et al.
    LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration

    Heather S Loring et al.
    The catalytic activity of SARM1, a key promoter of neuronal degeneration, is activated by >2000-fold by a phase transition.
    1. Structural Biology and Molecular Biophysics

    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

    Jun-ichi Kishikawa et al.
    Cryo-EM structures of rotary V-ATPase reveal the ON-OFF switching mechanism of H+ translocation in the Vo membrane domain.
    1. Developmental Biology
    2. Immunology and Inflammation

    Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

    Ken-ichi Hirano et al.
    Notch ligand, Dll4 needs the flexible loop structure in the MNNL domain of the extracellular region to efficiently trigger the Notch signaling.
    1. Ecology
    2. Evolutionary Biology

    Sex-specific effects of cooperative breeding and colonial nesting on prosociality in corvids

    Lisa Horn et al.
    A systematic experimental comparison of prosocial behavior in eight corvid species reveals sex-specific effects of cooperative breeding and colonial nesting, thereby adding important new insights regarding the evolution of prosociality.
    1. Structural Biology and Molecular Biophysics

    Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

    Cheng Dong et al.
    Complex structures of Tudor domains of PHF1/19 with H3tK27me3 provide structural basis for preferential recognition of H3tK27me3 over canonical H3K27me3, implicating that H3tK27me3 might be a physiological ligand of PHF1/19.
    1. Cell Biology
    2. Developmental Biology

    EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

    Yuki Osawa et al.
    EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
    1. Neuroscience

    Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control

    Rebecca A Callahan et al.
    Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.
    1. Chromosomes and Gene Expression

    Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

    Atsuko Shirai et al.
    Suv39h1 chromodomain possesses nucleic acid-binding activity and this activity is coupled with its H3K9 methylation recognition in assembling heterochromatin.
    1. Neuroscience

    Single caudate neurons encode temporally discounted value for formulating motivation for action

    Yukiko Hori et al.
    The dorsal part of the primate caudate head signals integrated multi-dimensional incentive factors essential for computing the motivation for action.

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