222 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

    Benjamin Albert et al.
    Ribosome assembly is monitored to promote proteostatis through a system whereby unassembled ribosomal proteins lead to activation of heat shock factor 1 and inactivation of the RP gene activator Ifh1.
    1. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Stem Cells and Regenerative Medicine

    Cell Fate Choice: Ready, set, differentiate!

    Margarida Sancho, Tristan A Rodríguez
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    1. Stem Cells and Regenerative Medicine

    Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin

    Mattias Malaguti et al.
    The differentiation decisions made by pluripotent cells depend on their exposure to appropriate extrinsic signals and also on morphogenetic events that control receptivity to those differentiation cues.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Brain Size: Gene losses did not stop the evolution of big brains

    Cristian Cañestro, Vittoria Roncalli
    Elephants and fruit bats have evolved large brains even though they have lost a gene that is fundamental to the supply of energy to the brain when glucose is not available.
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    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.

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