12 results found
    1. Immunology and Inflammation

    Tight nuclear tethering of cGAS is essential for preventing autoreactivity

    Hannah E Volkman et al.
    Tight nuclear tethering of the cGAS DNA sensor maintains it in its resting state and prevents activation by self-DNA.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

    Hyung Suk Oh et al.
    CRISPR genome editing technology can efficiently introduce mutations into lytic and latent HSV genomes to block lytic replication and reactivation of latent herpes simplex virus genome though differential mechanisms.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

    Murilo Delgobo et al.
    Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

    Simon Langer et al.
    By inhibiting the activation of NF-κB, HIV-1 Vpu exerts much broader immunosuppressive effects than previously anticipated and may be an important determinant of chronic inflammation in HIV-1 infected individuals.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle et al.
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.
    1. Immunology and Inflammation

    The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex

    Sarah A Stratmann et al.
    The scanning-assisted clustering mechanism of IFI16 not only allows efficient assembly on exposed foreign-dsDNA, but also suppresses the engagement of chromatinized self-dsDNA.

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