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    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana C Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Human myogenic progenitor cells display tenogenic differentiation potential and facilitate tendon regeneration

    Xiexiang Shao, Xingzuan Lin ... Ping Hu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

    Cenk Celik, Stella Tue Ting Lee ... Guillaume Thibault
    Enterococcus faecalis infection elicits a cellular response marked by novel bacterial-host interactions, revealing insights into immune evasion mechanisms in chronic wound infections.
    1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

    Niklas Lonnemann, Shirin Hosseini ... Martin Korte
    Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.
    1. Microbiology and Infectious Disease

    Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

    Alan M O'Neill, Kate A Worthing ... Richard L Gallo
    The discovery and development of a feline skin commensal bacterium for bacteriotherapy against skin disease, that could benefit patients due to established low cytotoxicity, broad-spectrum antimicrobial activity and anti-inflammatory activity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice

    Shauni Doms, Hanna Fokt ... John F Baines
    Genetic variation influencing the gut microbiome is abundant among incipient mammalian host species, and cospeciating bacterial taxa display a unique genetic architecture.
    1. Epidemiology and Global Health

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien, Alexey Lyashkov ... Luigi Ferrucci
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk, Meghan A Koch ... Gregory M Barton
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

    Annette Fischer, Kelly S Harrison ... Thomas Rudel
    Obligate intracellular Chlamydia secrete a deubiquitinating enzyme (Cdu1) into the membrane of the Chlamydia-containing vacuole to deubiquitinate selected host proteins and support the survival of the bacteria during genital infection.