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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

    Aurora Kraus, Benjamin Garcia ... Irene Salinas
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Inadequate
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana C Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Human myogenic progenitor cells display tenogenic differentiation potential and facilitate tendon regeneration

    Xiexiang Shao, Xingzuan Lin ... Ping Hu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

    Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten
    A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
    1. Neuroscience

    IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

    Niklas Lonnemann, Shirin Hosseini ... Martin Korte
    Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Novel insights from a multiomics dissection of the Hayflick limit

    Michelle Chan, Han Yuan ... David G Hendrickson
    A comprehensive molecular description of the cellular transition into replicative senescence provides evidence of metabolic, epigenetic, and regulatory rewiring that links senescence with wound healing and fibrosis.
    1. Cell Biology
    2. Neuroscience

    Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

    Luting Yang, Chunqing Hu ... Yaping Yan
    Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
    1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid