The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
The extent of (proteotoxic) endoplasmic reticulum stress, and the ensuing unfolded protein response activation, are commensurate with the extent of the chaperone BiP being sequestered by its client proteins.
The structures of secretory and dimeric IgA reveal pseudosymmetric assemblies of two antibody monomers, in which possible positions of antigen-binding fragments and accessibility to receptor-binding sites are limited.
In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.
Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.