The results presented here indicate that IL-10-producing CD4⁺ T cells express genes associated with chronically activated T_H1-like cells, undergo clonal expansion, and inhibit antiviral T cell responses via the secretion of arginase-1, facilitating viral persistence in mice infected with MCMV.

A novel B cell receptor induced interleukin 10 (IL-10) production from B10 cells involves signal transducer and activator of transcription 5 (STAT5) mediated IL-6 production which induces IL-10 in an autocrine and paracrine fashion from B10 cells.

miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.

NAD⁺ exhibits profound therapeutic effects in experimental septic shock models by dampening the systemic inflammatory response and leading to improved survival.

Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.

Natural Tr1-like cells do not form a functionally stable memory response to allergens, and this instability may limit efforts to re-establish tolerance by expanding Tr1.

Regulatory T cell suppress cytotoxic T cells in autoimmunity and cancer by taking up IL-2.

Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.

Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between IKZF1 and AP1.

Early suPAR-guided anakinra decreases the risk for severe respiratory failure in SARS-CoV-2 pneumonia and restores the pro-/anti-inflammatory balance.