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Metabolic switches between oxidative phosphorylation and aerobic glycolysis plus glutaminolysis direct T cell function by altering the flux of glucose and glutamine to N-glycosylation.

Downregulation of Sema4A in keratinocytes induces psoriatic non-lesional features, with its signaling cascades potentially triggering psoriasis and serving as targets for treatment and prevention.

A gradient-based approach is employed to characterize the organization of functional connectivity in the human locus coeruleus, revealing age-related differences and associations with cognitive and affective functions independently from age.

Intermittent fasting affects intestinal immunity through new interactions between macrophages and ILC3s, increasing ILC3 secretion of IL-22 and thus promoting white adipose tissue beigeing, and improving metabolism.

IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.

The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.

Mirlet7 functions as a molecular brake of CD8⁺IL17a⁺ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).

Immune expulsion of helminth parasites is driven by two key pathways mediated by soluble cytokines ligating to the IL-4 and IL-25 receptors acting on innate effector cells throughout the course of infection.

Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.

Strategies to enhance Tfh cells for HIV-vaccine antibody persistence and protection is pivotal for vaccine success.