2,413 results found
    1. Structural Biology and Molecular Biophysics

    Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state

    Agata Butryn et al.
    The structure of the entire Mot1 Swi2/Snf2 protein uncovers an unexpected auto-inhibited resting state activated by substrate binding, and suggests a DNA pulling mechanism of TBP displacement.
    1. Cancer Biology

    IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

    Ning Dai et al.
    The IGF2 mRNA binding protein-2/IMP2, overexpressed in many common cancers, drives cancer cell proliferation by increasing the abundance of IGF2 and the oncogene HMGA1, which controls a network of effectors that enhance IGF2 action.
    1. Chromosomes and Gene Expression

    PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

    Gergely Rona et al.
    Upon genotoxic stress, the FBXL10-RNF68-RNF2 ubiquitin ligase complex mono-ubiquitylates histone H2A and mediates H2A/H2A.Z exchange to repress transcription and ensures proper high fidelity homologous recombination repair.
    1. Developmental Biology
    2. Neuroscience

    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

    Akiko Terauchi et al.
    Feedback signaling between the synapse and nucleus via FGF22 and IGF2 directs the activity-dependent stabilization of presynaptic terminals in the mouse hippocampus.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Discovery of a small molecule that inhibits bacterial ribosome biogenesis

    Jonathan M Stokes et al.
    The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
    1. Developmental Biology

    Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

    Hua Shen et al.
    Neonatal mouse heart regeneration relies on the presence of mononuclear diploid cardiomyocytes, which unites this process with embryonic heart growth and adult heart regeneration.
    1. Cell Biology
    2. Developmental Biology

    Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

    Katherine Young Bezold Lamm et al.
    Loss of Inverted Formin-2 impairs intracellular trafficking and trophoblast invasion, resulting in maternal hypertension and intrauterine growth restriction, which represents a novel model of impaired placental invasion that encompasses critical aspects of the great obstetrical syndromes.
    1. Structural Biology and Molecular Biophysics

    Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

    Agata Butryn et al.
    A structural analysis of the transcription regulator Mot1 in complex with promoter DNA and the proteins TBP and NC2 provides a first structural framework for how a Swi2/Snf2 type remodeler interacts with a histone fold protein:DNA complex.
    1. Cancer Biology

    TINF2 is a haploinsufficient tumor suppressor that limits telomere length

    Isabelle Schmutz et al.
    Mutations in TIN2, a component of shelterin that keeps telomere length in check, lead to cancer-predisposition by disabling the telomere tumor suppressor pathway.
    1. Neuroscience

    A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

    Xiao-Wen Yu et al.
    Cation-independent-mannose-6-phosphate-receptor, or insulin-like-growth-factor-2-receptor (CIM6P/IGF2R) expressed in the hippocampus controls the protein metabolism regulated by learning and required for memory consolidation, and is also a key mechanism for memory enhancement.

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