18 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Calponin-homology domain mediated bending of membrane-associated actin filaments

    Saravanan Palani et al.
    Combination of actin and curly on lipid membranes constitutes a new, minimalistic system to generate high curvature actin rings that can contract upon the action of myosin II filaments.
    1. Cell Biology

    Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction

    Junqi Huang et al.
    Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis et al.
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Cell Biology
    2. Neuroscience

    Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines

    Sonia Afroz et al.
    Extrasynaptic GABAA receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
    1. Cell Biology

    Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

    Gareth Bloomfield et al.
    Inactivation of the Dictyostelium orthologue of the tumour suppressor Neurofibromin (NF1) enables amoebae to ingest dissolved nutrients using macropinocytosis more rapidly, and to prey on larger organisms using phagocytosis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Spectrin binding motifs regulate Scribble cortical dynamics and polarity function

    Batiste Boëda, Sandrine Etienne-Manneville
    A new protein–protein interaction motif identified in the polarity protein and tumor suppressor Scribble, and other cortical proteins, controls their interaction with spectrins and is crucial for the localization and function of Scribble.
    1. Developmental Biology

    Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

    Jiangnan Luo et al.
    Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
    1. Cell Biology

    Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

    Jenna R Christensen et al.
    The contractile ring actin binding proteins tropomyosin Cdc8 and a-actinin Ain1 synergize to effectively compete with the endocytic actin patch protein fimbrin Fim1 for associating with F-actin networks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad et al.
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.

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