A technique called selected reaction monitoring can quantitatively detect highly diversified protein isoforms and their association with specific neuronal structures and complexes.

CB₁-receptor-mediated inhibitory long-term depression (LTD) relies on both protein synthesis and ubiquitination to elicit structural changes that underlie long-term reduction of GABA release.

Inhibiting IRE1α decreases tumor cell proliferation and migration in hepatocellular carcinoma, therefore components of this ER-stress pathway may be therapeutically relevant for liver cancer.

MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.

Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.

IL-33 plays an important role in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.

Novel disease pathways underlie disease pathogenesis in Kelch-related nemaline myopathy through proteomic remodeling.

FABP4 plays a central role in driving the formation lipid-laden macrophages induced by unsaturated fats and enhances macrophage-tumor interactions, thereby promoting breast cancer migration and metastasis.