1,748 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys et al.
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.
    1. Structural Biology and Molecular Biophysics

    A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate

    Ritam Neupane et al.
    The ribosome bound structure of a new IRES reveals novel architecture features used by viruses to hijack cellular translation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke

    Paulo Wagner Pires, Scott Earley
    Acute hypoxia activates TRPA1 channels in cerebral artery endothelial cells to activate an early adaptive response to reduce tissue ischemic damage through vasodilation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An unfolded protein-induced conformational switch activates mammalian IRE1

    G Elif Karagöz et al.
    ER-stress sensing mechanism of the unfolded protein response sensor/transducer IRE1 is conserved from yeast to mammals, where in mammals, unfolded protein binding to IRE1's ER lumenal domain is coupled to its oligomerization and activation through an allosteric conformational change.
    1. Biochemistry and Chemical Biology

    A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

    Marisa D Ruehle et al.
    During initiation factor-independent RNA structure-driven translation initiation, a flexible RNA element drives the movement of a viral IRES through the ribosome's tRNA binding sites and promotes tRNA binding.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama et al.
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Cell Biology
    2. Developmental Biology

    Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans

    Mor Levi-Ferber et al.
    IRE-1 manipulates tumor cell identity to restore apoptosis sensitivity and suppress an aggressive germline tumor in C. elegans.
    1. Cell Biology

    Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

    Niko Amin-Wetzel et al.
    Client protein-driven reversal of endoplasmic reticulum chaperone (BiP) mediated-repression is revealed as a principal component of the regulation of the unfolded protein response transducer IRE1 in cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

    Priyanka D Abeyrathne et al.
    An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.
    1. Neuroscience

    Low-noise encoding of active touch by layer 4 in the somatosensory cortex

    Samuel Andrew Hires et al.
    Touch information is represented with minimal noise in the somatosensory cortex during tactile exploration.

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